Science diplomacy, as one of the key tools of foreign policy, plays an important role in strengthening international relations, exchanging knowledge, and solving global challenges. The United States, with the most advanced scientific and research infrastructure in the world, has used science diplomacy as a tool to advance its national interests.

In the structure of foreign policy implementation in the United States, the State Department plays a key role and, along with other organizations and institutions, pursues the goals and interests of the United States in foreign policy. This research sought to answer the question of what role the United States Department of State plays in the governance of science diplomacy in American foreign policy. The research method is qualitative and hypothesis-driven, and using a theoretical and conceptual framework within the overall framework of empirical research, it sought to describe and explain the position of the United States Department of State in the governance of science diplomacy. The information gathering tool in this regard was a library and using reliable sources available in articles and databases extracted from the Internet.

The results of the study show that the US State Department plays a key role in advancing science diplomacy as a strategic tool in the country's foreign policy. The department seeks to maintain and strengthen the scientific and technological position of the United States in the world by establishing and managing international scientific cooperation, participating in global organizations, and using new technologies in diplomatic relations. In a situation where scientific competition between great powers such as China and the European Union has increased, the US State Department, by implementing targeted policies in the field of science diplomacy, is trying to maintain the country's scientific superiority and use it as a tool to increase international influence.